RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

[Fe 3 F(H 2 O) 2 O(btc) 2 ]· n H 2 O (H 3 btc: benzene-1,3,5-tricarboxylic acid) (MIL-100(Fe)) in the form of nanoparticles with average size of 135 ± 70 nm can be used for the adsorption and controlled delivery of metallodrug [Ru( p -cymene)Cl 2 (pta)] (RAPTA-C) in simulated body fluid (SBF). The r...

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Bibliographic Details
Published in:New journal of chemistry 2016, Vol.4 (7), p.569-5694
Main Authors: Rojas, Sara, Carmona, Francisco J, Maldonado, Carmen R, Barea, Elisa, Navarro, Jorge A. R
Format: Article
Language:English
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Summary:[Fe 3 F(H 2 O) 2 O(btc) 2 ]· n H 2 O (H 3 btc: benzene-1,3,5-tricarboxylic acid) (MIL-100(Fe)) in the form of nanoparticles with average size of 135 ± 70 nm can be used for the adsorption and controlled delivery of metallodrug [Ru( p -cymene)Cl 2 (pta)] (RAPTA-C) in simulated body fluid (SBF). The results show that the RAPTA-C delivery process takes place in two steps exhibiting half-life times of 1.9 and 30 h. We also found a positive effect of bovine serum albumine (BSA) in speeding up the RAPTA-C delivery rate, which agrees with the suitability of MIL-100(Fe) as a drug delivery system (DDS) for the controlled release of RAPTA-C. The properties of MIL-100(Fe) nanoparticles as vehicles of a non-conventional half-sandwich ruthenium( ii ) metallodrug in simulated intravenous conditions have been investigated.
ISSN:1144-0546
1369-9261
DOI:10.1039/c5nj02741a