Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (...

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Bibliographic Details
Published in:New journal of chemistry 2016-01, Vol.4 (3), p.2823-2828
Main Authors: Nandeesh, Kebballi N, Swarup, Hassan A, Sandhya, Nagarakere C, Mohan, Chakrabhavi D, Pavan Kumar, Chottanahalli S, Kumara, Manikyanahalli N, Mantelingu, Kempegowda, Ananda, Sannaiah, Rangappa, Kanchugarakoppal S
Format: Article
Language:English
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Summary:A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (lung cancer) cell lines. Among them, compounds 3m (IC 50 , 9.7 μM) and 3h (IC 50 , 20.3 μM) were found to be the best antiproliferative agents. A new class of bis(imidazol)vinyl-1,2,4-oxadiazoles were synthesised and their anti-proliferative efficiency was tested against HCT116 and A549 cancer cell lines.
ISSN:1144-0546
1369-9261
DOI:10.1039/c5nj02925b