CsOH/γ-Al 2 O 3 : a heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines

A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/γ-Al 2 O 3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reaction of acetophenone, aromatic aldehydes and guanidine hydrochlo...

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Bibliographic Details
Published in:New journal of chemistry 2016, Vol.40 (3), p.2541-2546
Main Authors: Ramana, Amey Nimkar, M. M. V., Betkar, Rahul, Ranade, Prasanna, Mundhe, Balaji
Format: Article
Language:English
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Summary:A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/γ-Al 2 O 3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reaction of acetophenone, aromatic aldehydes and guanidine hydrochloride in ethanol. Characterization of the catalyst CsOH/γ-Al 2 O 3 was performed by using FT-IR, XRD, TG-DTA, SEM, BET surface area and CO 2 -TPD analysis techniques. The analytical data prove that the catalyst has excellent reusability and also indicate their good thermal stability.
ISSN:1144-0546
1369-9261
DOI:10.1039/C5NJ03565A