A catalyst-free, efficient green MCR protocol for access to functionalized γ-carbolines in water

A general, mild, efficient and practical approach for the construction of functionalized γ-carboline derivatives has been successfully realized in water through a one-pot three-component reaction involving several aryl/hetero-aryl/alkyl/alkenyl/alkynyl/ferrocenyl aldehydes, 3-formyl indole derivativ...

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Bibliographic Details
Published in:RSC advances 2015, Vol.5 (65), p.52497-52507
Main Authors: Dagar, Anuradha, Biswas, Soumen, Samanta, Sampak
Format: Article
Language:English
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Summary:A general, mild, efficient and practical approach for the construction of functionalized γ-carboline derivatives has been successfully realized in water through a one-pot three-component reaction involving several aryl/hetero-aryl/alkyl/alkenyl/alkynyl/ferrocenyl aldehydes, 3-formyl indole derivatives and ammonium acetate as a cheap N-source. The most important feature of the current methodology is that this hetero-annulation reaction of indole to γ-carboline can occur in good to excellent yields with wider substrate scope at room temperature in water, starting from simple inexpensive raw materials under catalyst-free and oxidant-free conditions. Moreover, a facile access to pentacyclic quinolinone fused carboline derivative has been achieved through our methodology.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA08422A