Facile synthesis and self-assembly of amphiphilic polydimethylsiloxane with poly(ethylene glycol) moieties via thiol-ene click reaction

We demonstrate here a facile and efficient synthesis of polysiloxane-based amphiphilic copolymers via thiol-ene click chemistry. The properties of PEG- b -PDMS- b -PEG ( T-PPG ) and PDMS- g -PEG ( S-PPG20 and S-PPG100 ) amphiphilic copolymers were studied in detail by a combination of 1 H NMR, FT-IR...

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Bibliographic Details
Published in:RSC advances 2015, Vol.5 (63), p.50955-50961
Main Authors: Xia, Yong, Yao, Hongtao, Miao, Zhihui, Ma, Yun, Cui, Meifang, Yan, Liqiang, Ling, Huanhuan, Qi, Zhengjian
Format: Article
Language:English
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Summary:We demonstrate here a facile and efficient synthesis of polysiloxane-based amphiphilic copolymers via thiol-ene click chemistry. The properties of PEG- b -PDMS- b -PEG ( T-PPG ) and PDMS- g -PEG ( S-PPG20 and S-PPG100 ) amphiphilic copolymers were studied in detail by a combination of 1 H NMR, FT-IR, gel permeation chromatography, and thermogravimetric analysis. In comparison with the traditional hydrosilylation method which requires the noble metal catalyst platinum, the newly designed thiol-ene protocol produces polysiloxane-based amphiphilic copolymers with only anti-Markovnikov addition products under benign conditions. The resulting copolymers have lower critical aggregation concentration (CAC), and dynamic light scattering (DLS) results revealed that the obtained amphiphilic copolymers can self-assemble into nanoparticles (128 nm to 198 nm) in aqueous solutions with a narrow size distribution (PDI is less than 0.24).
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA10150F