Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones

Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed via the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized via a silica-supported solid-phase reaction in good to excellent yields. T...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (14), p.11528-11535
Main Authors: Vinayaka, Ajjampura C., Swaroop, Toreshettahally R., Chikkade, Prasanna Kumara, Rangappa, Kanchugarakoppal S., Sadashiva, Maralinganadoddi P.
Format: Article
Language:English
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Summary:Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed via the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized via a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and N -methyl-2-aryl-4-quinolone alkaloid was achieved in high yield via an alumina-supported solid phase reaction. In addition, all the synthesized compounds were isolated directly in their pure form from the reaction mixture using an easy workup procedure.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA21421A