Nanoparticle based fluorescence resonance energy transfer (FRET) for biosensing applications

In the past few decades, Förster resonance energy transfer (FRET) has been used as a powerful tool for providing nanoscale information in many biosensing and bioanalysis applications. The performance of FRET assays is mainly dependent on the design of donor and acceptor pairs. Recently, a series of...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-01, Vol.3 (35), p.6989-75
Main Authors: Shi, Jingyu, Tian, Feng, Lyu, Jing, Yang, Mo
Format: Article
Language:English
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Summary:In the past few decades, Förster resonance energy transfer (FRET) has been used as a powerful tool for providing nanoscale information in many biosensing and bioanalysis applications. The performance of FRET assays is mainly dependent on the design of donor and acceptor pairs. Recently, a series of nanoparticles start to be used in FRET assays including semiconductor quantum dots (QDs), graphene quantum dots (GQDs), upconversion nanoparticles (UCNPs), gold nanoparticles (AuNPs) and graphene oxide (GO). The rapid pace of development in nanoparticles provides a lot of opportunities to revolutionize FRET techniques. Many nanoparticle based FRET assays have also been developed for various biosensing applications with higher sensitivity and better stability compared with traditional organic fluorophore based FRET assays. This article reviews the recent progress of nanoparticle FRET assays and their applications in biosensing area. Nanoparticle based FRET assays have higher energy transfer efficiency and better performance compared with traditional organic fluorophore based FRET assays.
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb00885a