Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: a new approach to magnetic sensing

Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a "loss of signal" in the sensing device. This report demonstrates the enzymatic conversion of Fe...

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Bibliographic Details
Published in:Analyst (London) 2016-09, Vol.141 (18), p.5246-5251
Main Authors: Kolhatkar, Arati G, Jamison, Andrew C, Nekrashevich, Ivan, Kourentzi, Katerina, Litvinov, Dmitri, Brazdeikis, Audrius, Willson, Richard C, Randall Lee, T
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alkaline Phosphatase - chemistry
Ascorbic Acid - chemistry
Conversion
Detection
Magnetite Nanoparticles
Nanoparticles
Precipitates
Precipitation
Sensing devices
Strategy
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Summary:Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a "loss of signal" in the sensing device. This report demonstrates the enzymatic conversion of Fe 3 O 4 MNPs to a non-magnetic precipitate via reduction by l -ascorbic acid generated by the action of alkaline phosphatase. Magnetic sensing utilizes loss of signal via enzymatic transformation of magnetic nanoparticles (MNPs).
ISSN:0003-2654
1364-5528
DOI:10.1039/c6an00709k