A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells

Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated tha...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (44), p.7134-7137
Main Authors: Kim, Hye-Ri, Kumar, Rajesh, Kim, Woori, Lee, Jae Hong, Suh, Myungkoo, Sharma, Amit, Kim, Chang Hoe, Kang, Chulhun, Seung Kim, Jong
Format: Article
Language:English
Subjects:
Biological
Emission
Endoplasmic reticulum
Fluorescence
Inducers
Markers
Membranes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin. Herein, we report a highly selective, far-red, photo- and bio-stable fluorescent marker for the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc02330d