Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

Auoxo3, a cytotoxic gold( iii ) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au( i ) ions bind...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (61), p.9518-9521
Main Authors: Ferraro, Giarita, Monti, Daria Maria, Amoresano, Angela, Pontillo, Nicola, Petruk, Ganna, Pane, Francesca, Cinellu, Maria Agostina, Merlino, Antonello
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Animals
Anticancer properties
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line
Cell Proliferation - drug effects
Cell Survival - drug effects
Crystallography, X-Ray
Dichroism
Dose-Response Relationship, Drug
Drug Carriers - chemistry
Drug Screening Assays, Antitumor
Encapsulation
Ferritin
Ferritins - chemistry
Gold - administration & dosage
Gold - chemistry
Gold - pharmacology
Humans
Inductively coupled plasma
Models, Molecular
Molecular Structure
Nanoparticles - chemistry
Nanostructure
Organogold Compounds - administration & dosage
Organogold Compounds - chemistry
Organogold Compounds - pharmacology
Rats
Structure-Activity Relationship
X-rays
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Summary:Auoxo3, a cytotoxic gold( iii ) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au( i ) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells. Auoxo3, a cytotoxic gold( iii ) compound, was encapsulated within a ferritin nanocage.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc02516a