Covalent post-assembly modification in metallosupramolecular chemistry

A growing variety of covalent reactions have been employed to achieve the post-assembly modification (PAM) of self-assembled metallosupramolecular complexes. Covalent PAM enables the late-stage derivatisation of pre-assembled parent complexes in a modular fashion, thus expanding the chemical space a...

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Bibliographic Details
Published in:Chemical Society reviews 2018-01, Vol.47 (2), p.626-644
Main Authors: Roberts, Derrick A, Pilgrim, Ben S, Nitschke, Jonathan R
Format: Article
Language:English
Subjects:
Chemical synthesis
Coordination compounds
Covalence
Self-assembly
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Summary:A growing variety of covalent reactions have been employed to achieve the post-assembly modification (PAM) of self-assembled metallosupramolecular complexes. Covalent PAM enables the late-stage derivatisation of pre-assembled parent complexes in a modular fashion, thus expanding the chemical space available for supramolecular synthesis. The oldest and most widespread implementation of covalent PAM is in metal-preorganised covalent synthesis. Recent work, however, has broadened the scope of covalent PAM to include: protocols for efficiently grafting new functionalities onto supramolecular architectures, reactions that permanently 'lock-down' metastable complexes, and covalent bond-forming stimuli that trigger controlled structural transformations between distinct supramolecular species. This review highlights key examples of each of these distinct kinds of covalent PAM in metallosupramolecular chemistry, before providing a perspective upon future challenges and opportunities. This review examines the growing variety of covalent reactions used to achieve the post-assembly modification of self-assembled metallosupramolecular complexes.
ISSN:0306-0012
1460-4744
DOI:10.1039/c6cs00907g