A new quinoline-based fluorescent probe for Cd 2+ and Hg 2+ with an opposite response in a 100% aqueous environment and live cell imaging

A new quinoline-based fluorescent probe L was synthesized and characterized. Probe L showed opposite fluorescence responses toward Cd 2+ (turn-on) and Hg 2+ (turn-off) in a 100% aqueous environment. X-ray crystallography analysis and TD-DFT calculations showed the different mechanisms of CHEF-based...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2016, Vol.45 (19), p.8174-8181
Main Authors: Lu, Hong-Lin, Wang, Wei-Kang, Tan, Xing-Xing, Luo, Xiao-Fei, Zhang, Mao-Lin, Zhang, Mei, Zang, Shuang-Quan
Format: Article
Language:English
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Summary:A new quinoline-based fluorescent probe L was synthesized and characterized. Probe L showed opposite fluorescence responses toward Cd 2+ (turn-on) and Hg 2+ (turn-off) in a 100% aqueous environment. X-ray crystallography analysis and TD-DFT calculations showed the different mechanisms of CHEF-based for L –Cd 2+ and PET-based for L –Hg 2+ caused by different binding modes and different electronic transfer patterns. The detection limits for the analysis of Cd 2+ and Hg 2+ ions were found to be 3.9 × 10 −8 M and 9.8 × 10 −7 M, respectively. Its in vivo sensitivities to Cd 2+ and Hg 2+ were demonstrated in the EC9706 cell line with the use of a laser scanning fluorescence microscope.
ISSN:1477-9226
1477-9234
DOI:10.1039/C6DT00362A