Directed alkynylation of unactivated C(sp)-H bonds with ethynylbenziodoxolones mediated by DTBP

A general and efficient method for the direct alkynylation of unactivated C(sp 3 )-H bonds under metal-free conditions is described. The reaction performs smoothly under mild conditions and shows excellent functional-group tolerance. Initial mechanistic investigation indicates that the reaction may...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2016, Vol.18 (15), p.4185-4188
Main Authors: Cheng, Zhi-Fei, Feng, Yi-Si, Rong, Chun, Xu, Tao, Wang, Peng-Fei, Xu, Jun, Dai, Jian-Jun, Xu, Hua-Jian
Format: Article
Language:English
Subjects:
Chemical bonds
Pathways
Radicals
Tolerances
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Summary:A general and efficient method for the direct alkynylation of unactivated C(sp 3 )-H bonds under metal-free conditions is described. The reaction performs smoothly under mild conditions and shows excellent functional-group tolerance. Initial mechanistic investigation indicates that the reaction may involve a radical pathway. A general and efficient alkynylation of unactivated C(sp 3 )-H bonds under metal-free conditions was developed herein.
ISSN:1463-9262
1463-9270
DOI:10.1039/c6gc01336h