Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

Complexes [ReCl(CO) 3 (H2AcPh)] ( 1 ), [ReCl(CO) 3 (H2Ac p ClPh)]0.5C 7 H 8 ( 2 ) and [ReCl(CO) 3 (H2Ac p NO 2 Ph)]0.5C 7 H 8 ( 3 ) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its para -chlorophenylhydrazone (H2Ac p ClPh) and para -nitrophenylhydrazone (H2Ac p NO 2 Ph) analogues...

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Bibliographic Details
Published in:New journal of chemistry 2016-01, Vol.4 (9), p.7379-7387
Main Authors: Garcia, Camila Vargas, Parrilha, Gabrieli Lessa, Rodrigues, Bernardo Lages, Teixeira, Sarah Fernandes, de Azevedo, Ricardo Alexandre, Ferreira, Adilson Kleber, Beraldo, Heloisa
Format: Article
Language:English
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Summary:Complexes [ReCl(CO) 3 (H2AcPh)] ( 1 ), [ReCl(CO) 3 (H2Ac p ClPh)]0.5C 7 H 8 ( 2 ) and [ReCl(CO) 3 (H2Ac p NO 2 Ph)]0.5C 7 H 8 ( 3 ) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its para -chlorophenylhydrazone (H2Ac p ClPh) and para -nitrophenylhydrazone (H2Ac p NO 2 Ph) analogues. Coordination to tricarbonylrhenium( i ) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes ( 2 ) and ( 3 ) induced apoptosis on NCI-H460 cells. Complex ( 2 ) induced mitochondrial damage while treatment with 3 showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes ( 2 ) and ( 3 ) showed a high antioxidant activity, 2 being more potent in reducing intracellular reactive oxygen species (ROS) production. Tricarbonylrhenium( i )-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge.
ISSN:1144-0546
1369-9261
DOI:10.1039/c6nj00050a