Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides

We report aqueous RAFT polymerization at pH = 0 mediated by a novel imidazolium-containing chain transfer agent. In 1 M HCl, unprecedented controlled polymerization and chain-extension of unprotected acyl hydrazide methacrylamides is achieved enabling the synthesis of well-defined acyl hydrazide fun...

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Bibliographic Details
Published in:Polymer chemistry 2017-09, Vol.8 (34), p.4978-4982
Main Authors: Hoff, Emily A., Abel, Brooks A., Tretbar, Chase A., McCormick, Charles L., Patton, Derek L.
Format: Article
Language:English
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Summary:We report aqueous RAFT polymerization at pH = 0 mediated by a novel imidazolium-containing chain transfer agent. In 1 M HCl, unprecedented controlled polymerization and chain-extension of unprotected acyl hydrazide methacrylamides is achieved enabling the synthesis of well-defined acyl hydrazide functionalized polymer scaffolds of interest for dynamic covalent and bioconjugation strategies.
ISSN:1759-9954
1759-9962
DOI:10.1039/C6PY01563H