Primaquine-based ionic liquids as a novel class of antimalarial hits

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Res...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (61), p.56134-56138
Main Authors: Ferraz, Ricardo, Noronha, Joana, Murtinheira, Fernanda, Nogueira, Fátima, Machado, Marta, Prudêncio, Miguel, Parapini, Silvia, D'Alessandro, Sarah, Teixeira, Cátia, Gomes, Ana, Prudêncio, Cristina, Gomes, Paula
Format: Article
Language:English
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Summary:Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs. Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical antimalarial drugs.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra10759a