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Green synthesis of primary, secondary, and tertiary amides through oxidative amidation of methyl groups with amine hydrochlorides over recyclable CoFe 2 O 4 NPs

A practical and efficient method is developed for efficient synthesis of a wide variety of 1°, 2°, and 3° amides through amidation of methylarenes with amine hydrochloride salts, over magnetic CoFe 2 O 4 NPs as a recyclable nanocatalyst, and aqueous tert -butyl hydroperoxide as an oxidant. This econ...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (108), p.106873-106879
Main Authors: Eidi, Esmaiel, Kassaee, Mohammad Zaman
Format: Article
Language:English
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Summary:A practical and efficient method is developed for efficient synthesis of a wide variety of 1°, 2°, and 3° amides through amidation of methylarenes with amine hydrochloride salts, over magnetic CoFe 2 O 4 NPs as a recyclable nanocatalyst, and aqueous tert -butyl hydroperoxide as an oxidant. This economically sound amidation reaction is operationally straightforward and provides desired amides in good to excellent yields, under mild conditions.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA20902E