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Green synthesis of primary, secondary, and tertiary amides through oxidative amidation of methyl groups with amine hydrochlorides over recyclable CoFe 2 O 4 NPs
A practical and efficient method is developed for efficient synthesis of a wide variety of 1°, 2°, and 3° amides through amidation of methylarenes with amine hydrochloride salts, over magnetic CoFe 2 O 4 NPs as a recyclable nanocatalyst, and aqueous tert -butyl hydroperoxide as an oxidant. This econ...
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Published in: | RSC advances 2016, Vol.6 (108), p.106873-106879 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A practical and efficient method is developed for efficient synthesis of a wide variety of 1°, 2°, and 3° amides through amidation of methylarenes with amine hydrochloride salts, over magnetic CoFe
2
O
4
NPs as a recyclable nanocatalyst, and aqueous
tert
-butyl hydroperoxide as an oxidant. This economically sound amidation reaction is operationally straightforward and provides desired amides in good to excellent yields, under mild conditions. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C6RA20902E |