An efficient CuI/DBU-catalyzed one-pot protocol for synthesis of 1,4-disubstituted 1,2,3-triazoles

A convenient CuI/DBU catalyzed one-pot method has been developed for the synthesis of 1,4-disubstituted 1,2,3-triazoles through the coupling of aryl iodides with sodium azide, followed by the intermolecular cyclization between the generated aryl azides and phenylacetaldehyde derivatives or alkynes i...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (111), p.110102-110107
Main Authors: Jiang, Yuqin, Li, Xingfeng, Zhao, Yaru, Jia, Shuhong, Li, Mingrui, Zhao, Zhiqi, Zhang, Ruili, Li, Wei, Zhang, Weiwei
Format: Article
Language:English
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Summary:A convenient CuI/DBU catalyzed one-pot method has been developed for the synthesis of 1,4-disubstituted 1,2,3-triazoles through the coupling of aryl iodides with sodium azide, followed by the intermolecular cyclization between the generated aryl azides and phenylacetaldehyde derivatives or alkynes in DMSO. The established protocol was compatible with a wide scope of substrates in good to excellent yields.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA23789D