Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids

The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for designing such systems are unclear. Here we show how to identify orthogonal self-assembly at the supramolecular level and describe guidelines...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2016-01, Vol.7 (9), p.621-631
Main Authors: Boekhoven, J, Brizard, A. M, Stuart, M. C. A, Florusse, L, Raffy, G, Del Guerzo, A, van Esch, J. H
Format: Article
Language:English
Subjects:
Architecture
Biomimetics
Chemistry
Guidelines
Liposomes
Phospholipids
Self assembly
Stability
Strategy
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Summary:The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for designing such systems are unclear. Here we show how to identify orthogonal self-assembly at the supramolecular level and describe guidelines to achieve self-sorting in self-assembled mixed systems. By investigating multicomponent self-assembled systems consisting of low molecular weight gelators and phospholipids, both at a molecular and a supramolecular level, we found that orthogonal self-assembly can only take place if the entities assemble via a strong and distinct set of interactions. The resulting supramolecular architectures consist of fibrillar networks that coexist with liposomes and thereby provide additional levels of compartmentalization and enhanced stability as compared to self-assembled systems of gelators or phospholipids alone. We report how to identify orthogonal self-assembly and describe guidelines to achieve self-sorting in self-assembled mixed systems.
ISSN:2041-6520
2041-6539
DOI:10.1039/c6sc01021k