A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of h...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-06, Vol.4 (22), p.3854-3858
Main Authors: Liu, Juan, Ma, Xiaowei, Lei, Chunni, Xue, Xiangdong, Wei, Tuo, Zhao, Jing, Li, Shuyi, Liang, Xing-Jie
Format: Article
Language:English
Subjects:
Biology
Cancer
Deoxyribonucleic acid
Doxorubicin
Drug delivery systems
Human
Medicine
Nanostructure
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Summary:We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of human lung adenocarcinoma epithelial cancer cells. The self-assembled DNA nanostructure was able to specifically target cancer cells and release the drug at pH 5.0.
ISSN:2050-750X
2050-7518
DOI:10.1039/c6tb00761a