MoS 2 /Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells

This work describes the adaptive use of a conventional stainless steel acupuncture needle as the electrode substrate for construction of a molybdenum disulfide (MoS ) and platinum nanoparticles (PtNPs) layer-modified microneedle sensor for real-time monitoring of hydrogen peroxide (H O ) release fro...

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Bibliographic Details
Published in:Analyst (London) 2017-11, Vol.142 (22), p.4322-4329
Main Authors: Zhou, Jin-Xiu, Tang, Li-Na, Yang, Fan, Liang, Feng-Xia, Wang, Hua, Li, Yu-Tao, Zhang, Guo-Jun
Format: Article
Language:English
Subjects:
Disulfides
Electrochemical Techniques
HeLa Cells
Humans
Hydrogen Peroxide - analysis
Metal Nanoparticles - chemistry
Molybdenum
Nanocomposites - chemistry
Needles
Platinum
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Summary:This work describes the adaptive use of a conventional stainless steel acupuncture needle as the electrode substrate for construction of a molybdenum disulfide (MoS ) and platinum nanoparticles (PtNPs) layer-modified microneedle sensor for real-time monitoring of hydrogen peroxide (H O ) release from living cells. To construct the nanocomposite-functionalized microneedle, the needle surface was first coated with a gold film by ion sputtering to enhance the conductivity. Subsequently, an electrochemical deposition method was successfully employed to deposit MoS nanosheet and Pt nanoparticles on the needle tip as the sensing interface. Electrochemical study demonstrated that the MoS /PtNPs nanocomposite-modified needle exhibited excellent catalytic performance and low over-potential toward the reduction of H O . Not only did the microneedle achieve a wide linear range from 1 to 100 μmol L with a limit of detection down to 0.686 μmol L , but it also realized the highly specific detection of H O . Owing to these remarkable analytical advantages, the prepared microneedle was applied to determine H O release from living cells with satisfactory results. The MoS /PtNPs nanocomposite-functionalized microneedle sensor is simple and affordable, and can serve as a promising electrochemical nonenzymatic sensing platform. Moreover, this superfine needle sensor shows great potential for real-time monitoring of reactive oxygen species in vivo with minimal damage.
ISSN:0003-2654
1364-5528
DOI:10.1039/C7AN01446E