Highly nucleophilic vitamin B 12 -assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

Reductive cross-coupling of aryl halides with ubiquitous alkyl tosylates was developed using a combination of nickel and vitamin B (VB : cyanocobalamin) catalysts. The tosylate was activated by reduced VB to form alkyl cobalt(iii), which served as a good alkylating agent for aryl-nickel species, lea...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-06, Vol.53 (48), p.6401-6404
Main Authors: Komeyama, Kimihiro, Ohata, Ryo, Kiguchi, Shinnosuke, Osaka, Itaru
Format: Article
Language:English
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Summary:Reductive cross-coupling of aryl halides with ubiquitous alkyl tosylates was developed using a combination of nickel and vitamin B (VB : cyanocobalamin) catalysts. The tosylate was activated by reduced VB to form alkyl cobalt(iii), which served as a good alkylating agent for aryl-nickel species, leading to C(sp )-C(sp ) bond formation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc01932g