Intrinsic optical sectioning with upconverting nanoparticles

Multiphoton microscopy is a powerful technique for imaging due to its deep penetration, low scattering and sectioning power, allowing control on all three axes for both imaging and molecular actuation, but involves expensive femtosecond lasers. We show that lanthanide-based Upconverting Nanoparticle...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-02, Vol.54 (15), p.1861-1864
Main Authors: Sorbello, C, Etchenique, R
Format: Article
Language:English
Subjects:
Actuation
Femtosecond pulsed lasers
Imaging
Nanoparticles
Optical sectioning
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Summary:Multiphoton microscopy is a powerful technique for imaging due to its deep penetration, low scattering and sectioning power, allowing control on all three axes for both imaging and molecular actuation, but involves expensive femtosecond lasers. We show that lanthanide-based Upconverting Nanoparticles offer an under $1000 solution with the main advantages of multiphoton imaging, including direct optical sectioning in complex 3D samples. Scanning laser upconversion microscopy yields true multiphoton sectioning power at very low excitation densities.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08443a