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A chemosensor for micro- to nano-molar detection of Ag + and Hg 2+ ions in pure aqueous media and its applications in cell imaging
The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography. The metal ion sensing ability of PTB-1 was explored by various experimental (naked-eye, UV-Vis, fluorescence, mass spectrometry and H N...
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Published in: | Dalton transactions : an international journal of inorganic chemistry 2017-10, Vol.46 (41), p.14201-14209 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography. The metal ion sensing ability of PTB-1 was explored by various experimental (naked-eye, UV-Vis, fluorescence, mass spectrometry and
H NMR spectroscopy) and theoretical (B3LYP/6-31G**/LANL2DZ) methods. PTB-1 exhibited a highly selective naked-eye detectable color change from colorless to dark brown and UV-Vis spectral changes for the detection of Ag
with a detection limit of 3.67 μM in aqueous medium. The detection of Ag
ions was achieved by test paper strip and supported silica methods. In contrast, PTB-1 exhibited a 23-fold enhanced emission at 420 nm in the presence of Hg
ions with a nano-molar detection limit of 0.69 nM. Finally, the sensor PTB-1 was applied successfully for the intracellular detection of Hg
ions in a HepG2 liver cell line, which was monitored by the use of confocal imaging techniques. |
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ISSN: | 1477-9226 1477-9234 |
DOI: | 10.1039/C7DT02524F |