Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners

An efficient, operationally simple and one-pot multi-component approach has been developed for the construction of pyrazolyl-thiazoles using sulfamic acid (H 2 NSO 3 H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with goo...

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Bibliographic Details
Published in:New journal of chemistry 2017, Vol.41 (10), p.3745-3749
Main Authors: Sridevi, B., Tangella, Yellaiah, Babu, Korrapati Suresh, Nanubolu, Jagadeesh Babu, Sunitha Rani, R., Ganesh Kumar, C., Meshram, H. M., Kamal, Ahmed
Format: Article
Language:English
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Summary:An efficient, operationally simple and one-pot multi-component approach has been developed for the construction of pyrazolyl-thiazoles using sulfamic acid (H 2 NSO 3 H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds ( 4a–z ) were synthesized and also evaluated for their cytotoxic activity against three human cancer cell lines. Among them, 4b , 4c and 4e exhibited considerable cytotoxicity with an IC 50 value of < 5 μM.
ISSN:1144-0546
1369-9261
DOI:10.1039/C7NJ00042A