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Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners
An efficient, operationally simple and one-pot multi-component approach has been developed for the construction of pyrazolyl-thiazoles using sulfamic acid (H 2 NSO 3 H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with goo...
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| Published in: | New journal of chemistry 2017, Vol.41 (10), p.3745-3749 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c231t-f0a4aa3410bbd7f25d1f4a16b6b6123937766a4f526a0518f7e08af90d3e27053 |
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| cites | cdi_FETCH-LOGICAL-c231t-f0a4aa3410bbd7f25d1f4a16b6b6123937766a4f526a0518f7e08af90d3e27053 |
| container_end_page | 3749 |
| container_issue | 10 |
| container_start_page | 3745 |
| container_title | New journal of chemistry |
| container_volume | 41 |
| creator | Sridevi, B. Tangella, Yellaiah Babu, Korrapati Suresh Nanubolu, Jagadeesh Babu Sunitha Rani, R. Ganesh Kumar, C. Meshram, H. M. Kamal, Ahmed |
| description | An efficient, operationally simple and one-pot multi-component approach has been developed for the construction of pyrazolyl-thiazoles using sulfamic acid (H
2
NSO
3
H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds (
4a–z
) were synthesized and also evaluated for their cytotoxic activity against three human cancer cell lines. Among them,
4b
,
4c
and
4e
exhibited considerable cytotoxicity with an IC
50
value of < 5 μM. |
| doi_str_mv | 10.1039/C7NJ00042A |
| format | article |
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2
NSO
3
H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds (
4a–z
) were synthesized and also evaluated for their cytotoxic activity against three human cancer cell lines. Among them,
4b
,
4c
and
4e
exhibited considerable cytotoxicity with an IC
50
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2
NSO
3
H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds (
4a–z
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4b
,
4c
and
4e
exhibited considerable cytotoxicity with an IC
50
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2
NSO
3
H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds (
4a–z
) were synthesized and also evaluated for their cytotoxic activity against three human cancer cell lines. Among them,
4b
,
4c
and
4e
exhibited considerable cytotoxicity with an IC
50
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| ispartof | New journal of chemistry, 2017, Vol.41 (10), p.3745-3749 |
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| language | eng |
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| source | Royal Society of Chemistry |
| title | Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners |
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