Fast determination of fipronil and its metabolites in seafood using PRiME pass-through cleanup followed by isotope dilution UHPLC-MS/MS

A simple and effective method based on the PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure followed by ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) was developed for analyzing fipronil and its met...

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Bibliographic Details
Published in:Analytical methods 2018-01, Vol.1 (15), p.1673-1679
Main Authors: Zhang, Yun, Zhao, Yong-Gang, Cheng, He-Li, Muhammad, Nadeem, Chen, Wei-Sheng, Zeng, Xiu-Qiong, Zhu, Yan
Format: Article
Language:English
Subjects:
Cleanup
Dilution
Fipronil
High performance liquid chromatography
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolites
Pesticides
Quadrupoles
Seafood
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Summary:A simple and effective method based on the PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure followed by ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) was developed for analyzing fipronil and its metabolites in seafoods. Matrix effects in seafoods were effectively improved. Validation results demonstrated that this method was suitable for monitoring fipronil residues in seafoods. A simple and effective method based on the PRiME pass-through cleanup procedure followed by UHPLC-MS/MS was developed for analyzing fipronil and its metabolites in seafoods.
ISSN:1759-9660
1759-9679
DOI:10.1039/c8ay00445e