A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens

Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive...

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Bibliographic Details
Published in:Biomaterials science 2019-01, Vol.7 (2), p.581-584
Main Authors: Hu, Jingjing, Zheng, Zhao, Liu, Cenxi, Hu, Qianyu, Cai, Xiaopan, Xiao, Jianru, Cheng, Yiyun
Format: Article
Language:English
Subjects:
Aerobiosis
Aminoglycosides
Anaerobiosis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Bacteria - drug effects
Bacteria - growth & development
Bacteria - metabolism
Biocompatibility
Drug delivery systems
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogen-Ion Concentration
Imines
Pathogens
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Summary:Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue via an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels. A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens.
ISSN:2047-4830
2047-4849
DOI:10.1039/c8bm01211c