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A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens
Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive...
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| Published in: | Biomaterials science 2019-01, Vol.7 (2), p.581-584 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c337t-35704f3704eb2929a58c348cb113e7a5cdf3250dc98ff6b551f2ac61495dd8a3 |
| container_end_page | 584 |
| container_issue | 2 |
| container_start_page | 581 |
| container_title | Biomaterials science |
| container_volume | 7 |
| creator | Hu, Jingjing Zheng, Zhao Liu, Cenxi Hu, Qianyu Cai, Xiaopan Xiao, Jianru Cheng, Yiyun |
| description | Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue
via
an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.
A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens. |
| doi_str_mv | 10.1039/c8bm01211c |
| format | article |
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via
an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.
A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/c8bm01211c</identifier><identifier>PMID: 30460937</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aerobiosis ; Aminoglycosides ; Anaerobiosis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria - drug effects ; Bacteria - growth & development ; Bacteria - metabolism ; Biocompatibility ; Drug delivery systems ; Hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; Hydrogen-Ion Concentration ; Imines ; Pathogens</subject><ispartof>Biomaterials science, 2019-01, Vol.7 (2), p.581-584</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-35704f3704eb2929a58c348cb113e7a5cdf3250dc98ff6b551f2ac61495dd8a3</citedby><cites>FETCH-LOGICAL-c337t-35704f3704eb2929a58c348cb113e7a5cdf3250dc98ff6b551f2ac61495dd8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30460937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jingjing</creatorcontrib><creatorcontrib>Zheng, Zhao</creatorcontrib><creatorcontrib>Liu, Cenxi</creatorcontrib><creatorcontrib>Hu, Qianyu</creatorcontrib><creatorcontrib>Cai, Xiaopan</creatorcontrib><creatorcontrib>Xiao, Jianru</creatorcontrib><creatorcontrib>Cheng, Yiyun</creatorcontrib><title>A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue
via
an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.
A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens.</description><subject>Aerobiosis</subject><subject>Aminoglycosides</subject><subject>Anaerobiosis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - growth & development</subject><subject>Bacteria - metabolism</subject><subject>Biocompatibility</subject><subject>Drug delivery systems</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Imines</subject><subject>Pathogens</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpd0U1LwzAYB_AgipO5i3el4EWEat7aJMdZ1AkTL7uXNE23jK6pSTbZtze6F8FAkifkx5-QB4ArBB8QJOJR8WoFEUZInYALDClLKafi9FgTOAAj75cwDsYEzNE5GBBIcygIuwCLcdJPUqd9bztvNjpZbGtn57pNvkxYJL0NuguJ7IKppAraGdkmsTAbE7aJnEvT-ZBUNlKpna2MiraO83DqZVjEuM5fgrNGtl6P9vsQzF6eZ8UknX68vhXjaaoIYSElGYO0IXHRFRZYyIwrQrmqECKayUzVDcEZrJXgTZNXWYYaLFWOqMjqmksyBHe72N7Zz7X2oVwZr3Tbyk7btS8xInlGBWck0tt_dGnXrouPi4phzDmhMKr7nVLOeu90U_bOrKTblgiWPx0oC_70_tuBIuKbfeS6Wun6SA__HcH1Djivjrd_LSTfbQqKqw</recordid><startdate>20190129</startdate><enddate>20190129</enddate><creator>Hu, Jingjing</creator><creator>Zheng, Zhao</creator><creator>Liu, Cenxi</creator><creator>Hu, Qianyu</creator><creator>Cai, Xiaopan</creator><creator>Xiao, Jianru</creator><creator>Cheng, Yiyun</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope></search><sort><creationdate>20190129</creationdate><title>A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens</title><author>Hu, Jingjing ; Zheng, Zhao ; Liu, Cenxi ; Hu, Qianyu ; Cai, Xiaopan ; Xiao, Jianru ; Cheng, Yiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-35704f3704eb2929a58c348cb113e7a5cdf3250dc98ff6b551f2ac61495dd8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aerobiosis</topic><topic>Aminoglycosides</topic><topic>Anaerobiosis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - growth & development</topic><topic>Bacteria - metabolism</topic><topic>Biocompatibility</topic><topic>Drug delivery systems</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Imines</topic><topic>Pathogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Jingjing</creatorcontrib><creatorcontrib>Zheng, Zhao</creatorcontrib><creatorcontrib>Liu, Cenxi</creatorcontrib><creatorcontrib>Hu, Qianyu</creatorcontrib><creatorcontrib>Cai, Xiaopan</creatorcontrib><creatorcontrib>Xiao, Jianru</creatorcontrib><creatorcontrib>Cheng, Yiyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Jingjing</au><au>Zheng, Zhao</au><au>Liu, Cenxi</au><au>Hu, Qianyu</au><au>Cai, Xiaopan</au><au>Xiao, Jianru</au><au>Cheng, Yiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2019-01-29</date><risdate>2019</risdate><volume>7</volume><issue>2</issue><spage>581</spage><epage>584</epage><pages>581-584</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue
via
an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.
A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30460937</pmid><doi>10.1039/c8bm01211c</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4830 |
| ispartof | Biomaterials science, 2019-01, Vol.7 (2), p.581-584 |
| issn | 2047-4830 2047-4849 |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Aerobiosis Aminoglycosides Anaerobiosis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacteria - drug effects Bacteria - growth & development Bacteria - metabolism Biocompatibility Drug delivery systems Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Hydrogen-Ion Concentration Imines Pathogens |
| title | A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens |
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