Tetrahydro-3 H -pyrazolo[4,3- a ]phenanthridine-based CDK inhibitor

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992 , containing a novel scaffold based on the tetrahydro-3 H -pyrazolo[4,3- a ]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (36), p.4521-4524
Main Authors: Opoku-Temeng, Clement, Dayal, Neetu, Hernandez, Delmis E., Naganna, N., Sintim, Herman O.
Format: Article
Language:English
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Summary:Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992 , containing a novel scaffold based on the tetrahydro-3 H -pyrazolo[4,3- a ]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.
ISSN:1359-7345
1364-548X
DOI:10.1039/C8CC01154K