Real-time visualization of autophagy by monitoring the fluctuation of lysosomal pH with a ratiometric two-photon fluorescent probe

A benzimidazole-decorated two-photon fluorescent probe ( Lyso-MPCB ) based on the p -methoxyphenylacetylene-substituted carbazole was developed for detecting lysosomal pH with a double-channel signal, which can be used to visualize autophagy by real-time imaging the fluctuation of the pH in the lyso...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-02, Vol.55 (12), p.1782-1785
Main Authors: Ning, Peng, Hou, Liling, Feng, Yan, Xu, Guoyong, Bai, Yuyuan, Yu, Haizhu, Meng, Xiangming
Format: Article
Language:English
Subjects:
Autophagy
Carbazoles
Fluorescent indicators
Lysosomes
NMR
Nuclear magnetic resonance
Real time
Selectivity
Titration
Toxicity
Variation
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Summary:A benzimidazole-decorated two-photon fluorescent probe ( Lyso-MPCB ) based on the p -methoxyphenylacetylene-substituted carbazole was developed for detecting lysosomal pH with a double-channel signal, which can be used to visualize autophagy by real-time imaging the fluctuation of the pH in the lysosomes. A ratiometric two-photon fluorescent probe ( Lyso-MPCB ) was developed for visualizing autophagy by real-time imaging the fluctuation of lysosomal pH.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09517e