Hydrated ionic liquids enable both solubilisation and refolding of aggregated concanavalin A

The dissolution and refolding of aggregated concanavalin A have been achieved, in hydrated ionic liquids containing a limited number of water molecules. Both ammonium and phosphonium salts were examined to find a suitable hydrophobicity of ions and water content for refolding. Recovery of sugar reco...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-03, Vol.55 (25), p.3578-3581
Main Authors: Fujita, Kyoko, Nakano, Roka, Nakaba, Risa, Nakamura, Nobuhumi, Ohno, Hiroyuki
Format: Article
Language:English
Subjects:
Concanavalin A
Hydrophobicity
Ionic liquids
Ions
Moisture content
Solubilization
Solvents
Water chemistry
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Summary:The dissolution and refolding of aggregated concanavalin A have been achieved, in hydrated ionic liquids containing a limited number of water molecules. Both ammonium and phosphonium salts were examined to find a suitable hydrophobicity of ions and water content for refolding. Recovery of sugar recognition was confirmed as a proof of refolding. Dissolution and refolding of aggregated concanavalin A were demonstrated in hydrated ionic liquids.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc10102g