Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs

Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent y...

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Bibliographic Details
Published in:Chemical Society reviews 2019-02, Vol.48 (4), p.177-194
Main Authors: Ji, Xingyue, Pan, Zhixiang, Yu, Bingchen, De La Cruz, Ladie Kimberly, Zheng, Yueqin, Ke, Bowen, Wang, Binghe
Format: Article
Language:English
Subjects:
Chemical compounds
Cleavage
Control stability
Drugs
Functional groups
Organic chemistry
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Summary:Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, "click and release" approaches have shown great promise in the design of prodrugs because of their bioorthogonality and controlled bond-cleavage, which help ensure prodrug stability during circulation and ready cleavage at the desired site of action. This review highlights recent developments of this research field and discusses issues yet to be addressed. This review summarizes recent developments in using bioorthogonal chemistry in prodrug design for the delivery of traditional small molecule- and gasotransmitter-based therapeutics.
ISSN:0306-0012
1460-4744
DOI:10.1039/c8cs00395e