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Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties
This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective effects in alloxa...
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| Published in: | Food & function 2018-04, Vol.9 (4), p.251-269 |
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| container_end_page | 269 |
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| creator | Mejri, Faiza Selmi, Slimen Martins, Alice benkhoud, Haifa Baati, Tarek Chaabane, Hedia Njim, Leila Serralheiro, Maria L. M Rauter, Amélia P Hosni, Karim |
| description | This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the
in vitro
(antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and
in vivo
(anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content
versus
low fat content ( |
| doi_str_mv | 10.1039/c8fo00055g |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C8FO00055G</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2030552227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-c4d11005ffe24d2f70b0e3bb460a3d0cfce1fdfb4cfc0d316a380a92d2fdea713</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi0EolXphTvIEpeCmuKPbBJzKyvaIq3UC0jcIn-MG1dJvNheyvJn-KtMu_2QOM07mscz1vsS8pqzE86k-mg7Hxlji8XVM7IvWC2qZsF-PH_QtWr2yGHO18ggrjrVvSR7Qi061Ui-T_5-TlE7akDP9IiuTt7TdXT5E9U0BTvQHDfJAo2emhC1LeEX0DBfJXAB5pLpTSgD1XMJU7ApmqDH47s2_g4O6zGF-c92un0zBBNKTNvdvHJBGyjBYufoAHosQ7VOcYoF11NUa0glQH5FXng9Zji8rwfk-9mXb8uLanV5_nV5uqqslG2pbO04Rxe8B1E74VtmGEhj6oZp6Zj1Frh33tSomJO80bJjWglEHeiWywNytNuLp39uIJd-CtnCOOoZ4ib3gnFVt4Irhei7_9BrdGnG3yElMQkhRIvUhx2FvuScwPfrFCadtj1n_W1y_bI7u7xL7hzht_crN2YC94g-5ITAmx2Qsn2cPkUv_wGibKAE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2030552227</pqid></control><display><type>article</type><title>Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties</title><source>Royal Society of Chemistry</source><creator>Mejri, Faiza ; Selmi, Slimen ; Martins, Alice ; benkhoud, Haifa ; Baati, Tarek ; Chaabane, Hedia ; Njim, Leila ; Serralheiro, Maria L. M ; Rauter, Amélia P ; Hosni, Karim</creator><creatorcontrib>Mejri, Faiza ; Selmi, Slimen ; Martins, Alice ; benkhoud, Haifa ; Baati, Tarek ; Chaabane, Hedia ; Njim, Leila ; Serralheiro, Maria L. M ; Rauter, Amélia P ; Hosni, Karim</creatorcontrib><description>This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the
in vitro
(antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and
in vivo
(anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content
versus
low fat content (<1%) contributing to a low energy value of 139.24 kcal per 100 g. Profiling of fatty acids showed an abundance of the essential polyunsaturated α-linolenic and linoleic acids, exhibiting an excellent nutritional quality as revealed by their low atherogenic and thrombogenic indices and their hypocholesterolemic properties. The methanol extract which exhibited the highest total phenolic, flavonoid and tannin contents was found to be the most active extract in terms of antimicrobial and anti-radical activities. In alloxan-induced diabetic mice, the oral administration of a methanol extract (500 mg per kg bw) attenuated the elevated levels of serum alanine aminotransferase (ALA), aspartate aminotransferase (AST), and alkaline phosphatase activities, and urea, uric acid, and creatinine. It effectively normalized the status of lipid profiles, mitigated oxidative stress through the activation of antioxidant enzymes (CAT, GPx and SOD), and alleviated oxidative stress-mediated histopathological changes in the pancreas, liver, kidney and testis. Compositional analysis by HPLC-PDA-ESI-MS/MS revealed the presence of flavan-3-ols (catechin, epicatechin and their derivatives), flavones (apigenin derivatives) and flavonols (glycosides of quercetin and kaempferol), among others. These findings suggest that BBPs may be an effective functional food for the management of diabetes and its complications.
Broad bean pods have been proven to be a functional food with promising
in vitro
and
in vivo
biological activities.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/c8fo00055g</identifier><identifier>PMID: 29589631</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acetylcholinesterase ; Alanine ; Alanine transaminase ; Alkaline phosphatase ; Alloxan ; Antiinfectives and antibacterials ; Antioxidants ; Aspartate aminotransferase ; Biological effects ; Carbohydrates ; Catechin ; Complications ; Creatinine ; Derivatives ; Diabetes ; Diabetes mellitus ; Dietary fiber ; Energy value ; Epicatechin ; Fatty acids ; Flavones ; Flavonols ; Food ; Food production ; Glycosides ; Health promotion ; High-performance liquid chromatography ; Kaempferol ; Kidneys ; Liquid chromatography ; Liver ; Low fat ; Methanol ; Mice ; Minerals ; Oral administration ; Oxidative stress ; Pancreas ; Phenols ; Urea ; Uric acid ; Vicia faba</subject><ispartof>Food & function, 2018-04, Vol.9 (4), p.251-269</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-c4d11005ffe24d2f70b0e3bb460a3d0cfce1fdfb4cfc0d316a380a92d2fdea713</citedby><cites>FETCH-LOGICAL-c337t-c4d11005ffe24d2f70b0e3bb460a3d0cfce1fdfb4cfc0d316a380a92d2fdea713</cites><orcidid>0000-0003-0978-8378 ; 0000-0001-7541-9613</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29589631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mejri, Faiza</creatorcontrib><creatorcontrib>Selmi, Slimen</creatorcontrib><creatorcontrib>Martins, Alice</creatorcontrib><creatorcontrib>benkhoud, Haifa</creatorcontrib><creatorcontrib>Baati, Tarek</creatorcontrib><creatorcontrib>Chaabane, Hedia</creatorcontrib><creatorcontrib>Njim, Leila</creatorcontrib><creatorcontrib>Serralheiro, Maria L. M</creatorcontrib><creatorcontrib>Rauter, Amélia P</creatorcontrib><creatorcontrib>Hosni, Karim</creatorcontrib><title>Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the
in vitro
(antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and
in vivo
(anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content
versus
low fat content (<1%) contributing to a low energy value of 139.24 kcal per 100 g. Profiling of fatty acids showed an abundance of the essential polyunsaturated α-linolenic and linoleic acids, exhibiting an excellent nutritional quality as revealed by their low atherogenic and thrombogenic indices and their hypocholesterolemic properties. The methanol extract which exhibited the highest total phenolic, flavonoid and tannin contents was found to be the most active extract in terms of antimicrobial and anti-radical activities. In alloxan-induced diabetic mice, the oral administration of a methanol extract (500 mg per kg bw) attenuated the elevated levels of serum alanine aminotransferase (ALA), aspartate aminotransferase (AST), and alkaline phosphatase activities, and urea, uric acid, and creatinine. It effectively normalized the status of lipid profiles, mitigated oxidative stress through the activation of antioxidant enzymes (CAT, GPx and SOD), and alleviated oxidative stress-mediated histopathological changes in the pancreas, liver, kidney and testis. Compositional analysis by HPLC-PDA-ESI-MS/MS revealed the presence of flavan-3-ols (catechin, epicatechin and their derivatives), flavones (apigenin derivatives) and flavonols (glycosides of quercetin and kaempferol), among others. These findings suggest that BBPs may be an effective functional food for the management of diabetes and its complications.
Broad bean pods have been proven to be a functional food with promising
in vitro
and
in vivo
biological activities.</description><subject>Acetylcholinesterase</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Alloxan</subject><subject>Antiinfectives and antibacterials</subject><subject>Antioxidants</subject><subject>Aspartate aminotransferase</subject><subject>Biological effects</subject><subject>Carbohydrates</subject><subject>Catechin</subject><subject>Complications</subject><subject>Creatinine</subject><subject>Derivatives</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Dietary fiber</subject><subject>Energy value</subject><subject>Epicatechin</subject><subject>Fatty acids</subject><subject>Flavones</subject><subject>Flavonols</subject><subject>Food</subject><subject>Food production</subject><subject>Glycosides</subject><subject>Health promotion</subject><subject>High-performance liquid chromatography</subject><subject>Kaempferol</subject><subject>Kidneys</subject><subject>Liquid chromatography</subject><subject>Liver</subject><subject>Low fat</subject><subject>Methanol</subject><subject>Mice</subject><subject>Minerals</subject><subject>Oral administration</subject><subject>Oxidative stress</subject><subject>Pancreas</subject><subject>Phenols</subject><subject>Urea</subject><subject>Uric acid</subject><subject>Vicia faba</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkU1v1DAQhi0EolXphTvIEpeCmuKPbBJzKyvaIq3UC0jcIn-MG1dJvNheyvJn-KtMu_2QOM07mscz1vsS8pqzE86k-mg7Hxlji8XVM7IvWC2qZsF-PH_QtWr2yGHO18ggrjrVvSR7Qi061Ui-T_5-TlE7akDP9IiuTt7TdXT5E9U0BTvQHDfJAo2emhC1LeEX0DBfJXAB5pLpTSgD1XMJU7ApmqDH47s2_g4O6zGF-c92un0zBBNKTNvdvHJBGyjBYufoAHosQ7VOcYoF11NUa0glQH5FXng9Zji8rwfk-9mXb8uLanV5_nV5uqqslG2pbO04Rxe8B1E74VtmGEhj6oZp6Zj1Frh33tSomJO80bJjWglEHeiWywNytNuLp39uIJd-CtnCOOoZ4ib3gnFVt4Irhei7_9BrdGnG3yElMQkhRIvUhx2FvuScwPfrFCadtj1n_W1y_bI7u7xL7hzht_crN2YC94g-5ITAmx2Qsn2cPkUv_wGibKAE</recordid><startdate>20180425</startdate><enddate>20180425</enddate><creator>Mejri, Faiza</creator><creator>Selmi, Slimen</creator><creator>Martins, Alice</creator><creator>benkhoud, Haifa</creator><creator>Baati, Tarek</creator><creator>Chaabane, Hedia</creator><creator>Njim, Leila</creator><creator>Serralheiro, Maria L. M</creator><creator>Rauter, Amélia P</creator><creator>Hosni, Karim</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0978-8378</orcidid><orcidid>https://orcid.org/0000-0001-7541-9613</orcidid></search><sort><creationdate>20180425</creationdate><title>Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties</title><author>Mejri, Faiza ; Selmi, Slimen ; Martins, Alice ; benkhoud, Haifa ; Baati, Tarek ; Chaabane, Hedia ; Njim, Leila ; Serralheiro, Maria L. M ; Rauter, Amélia P ; Hosni, Karim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-c4d11005ffe24d2f70b0e3bb460a3d0cfce1fdfb4cfc0d316a380a92d2fdea713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetylcholinesterase</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Alloxan</topic><topic>Antiinfectives and antibacterials</topic><topic>Antioxidants</topic><topic>Aspartate aminotransferase</topic><topic>Biological effects</topic><topic>Carbohydrates</topic><topic>Catechin</topic><topic>Complications</topic><topic>Creatinine</topic><topic>Derivatives</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Dietary fiber</topic><topic>Energy value</topic><topic>Epicatechin</topic><topic>Fatty acids</topic><topic>Flavones</topic><topic>Flavonols</topic><topic>Food</topic><topic>Food production</topic><topic>Glycosides</topic><topic>Health promotion</topic><topic>High-performance liquid chromatography</topic><topic>Kaempferol</topic><topic>Kidneys</topic><topic>Liquid chromatography</topic><topic>Liver</topic><topic>Low fat</topic><topic>Methanol</topic><topic>Mice</topic><topic>Minerals</topic><topic>Oral administration</topic><topic>Oxidative stress</topic><topic>Pancreas</topic><topic>Phenols</topic><topic>Urea</topic><topic>Uric acid</topic><topic>Vicia faba</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mejri, Faiza</creatorcontrib><creatorcontrib>Selmi, Slimen</creatorcontrib><creatorcontrib>Martins, Alice</creatorcontrib><creatorcontrib>benkhoud, Haifa</creatorcontrib><creatorcontrib>Baati, Tarek</creatorcontrib><creatorcontrib>Chaabane, Hedia</creatorcontrib><creatorcontrib>Njim, Leila</creatorcontrib><creatorcontrib>Serralheiro, Maria L. M</creatorcontrib><creatorcontrib>Rauter, Amélia P</creatorcontrib><creatorcontrib>Hosni, Karim</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mejri, Faiza</au><au>Selmi, Slimen</au><au>Martins, Alice</au><au>benkhoud, Haifa</au><au>Baati, Tarek</au><au>Chaabane, Hedia</au><au>Njim, Leila</au><au>Serralheiro, Maria L. M</au><au>Rauter, Amélia P</au><au>Hosni, Karim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2018-04-25</date><risdate>2018</risdate><volume>9</volume><issue>4</issue><spage>251</spage><epage>269</epage><pages>251-269</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the
in vitro
(antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and
in vivo
(anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content
versus
low fat content (<1%) contributing to a low energy value of 139.24 kcal per 100 g. Profiling of fatty acids showed an abundance of the essential polyunsaturated α-linolenic and linoleic acids, exhibiting an excellent nutritional quality as revealed by their low atherogenic and thrombogenic indices and their hypocholesterolemic properties. The methanol extract which exhibited the highest total phenolic, flavonoid and tannin contents was found to be the most active extract in terms of antimicrobial and anti-radical activities. In alloxan-induced diabetic mice, the oral administration of a methanol extract (500 mg per kg bw) attenuated the elevated levels of serum alanine aminotransferase (ALA), aspartate aminotransferase (AST), and alkaline phosphatase activities, and urea, uric acid, and creatinine. It effectively normalized the status of lipid profiles, mitigated oxidative stress through the activation of antioxidant enzymes (CAT, GPx and SOD), and alleviated oxidative stress-mediated histopathological changes in the pancreas, liver, kidney and testis. Compositional analysis by HPLC-PDA-ESI-MS/MS revealed the presence of flavan-3-ols (catechin, epicatechin and their derivatives), flavones (apigenin derivatives) and flavonols (glycosides of quercetin and kaempferol), among others. These findings suggest that BBPs may be an effective functional food for the management of diabetes and its complications.
Broad bean pods have been proven to be a functional food with promising
in vitro
and
in vivo
biological activities.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29589631</pmid><doi>10.1039/c8fo00055g</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-0978-8378</orcidid><orcidid>https://orcid.org/0000-0001-7541-9613</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2018-04, Vol.9 (4), p.251-269 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C8FO00055G |
| source | Royal Society of Chemistry |
| subjects | Acetylcholinesterase Alanine Alanine transaminase Alkaline phosphatase Alloxan Antiinfectives and antibacterials Antioxidants Aspartate aminotransferase Biological effects Carbohydrates Catechin Complications Creatinine Derivatives Diabetes Diabetes mellitus Dietary fiber Energy value Epicatechin Fatty acids Flavones Flavonols Food Food production Glycosides Health promotion High-performance liquid chromatography Kaempferol Kidneys Liquid chromatography Liver Low fat Methanol Mice Minerals Oral administration Oxidative stress Pancreas Phenols Urea Uric acid Vicia faba |
| title | Broad bean ( L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties |
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