Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two aldehydes were involved in this reaction and a...

Full description

Saved in:
Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2018, Vol.2 (24), p.5459-5463
Main Authors: Chen, Jinjin, Chang, Dan, Xiao, Fuhong, Deng, Guo-Jun
Format: Article
Language:English
Subjects:
Aldehydes
Ammonium
Green chemistry
Hydrogen bonds
Iodides
Metals
Nitrogen sources
Substitutes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two aldehydes were involved in this reaction and ammonium iodide was used as one of the nitrogen sources. This reaction provides a strategy for the facile construction of substituted quinazolines from simple anilines and other readily available reactants. Substituted quinazoline derivatives were selectively prepared from anilines, aromatic aldehydes and NH 4 I under metal-free conditions.
ISSN:1463-9262
1463-9270
DOI:10.1039/c8gc02654h