UV 365 light promoted catalyst-free synthesis of pyrimido[4,5- b ]quinoline-2,4-diones in aqueous-glycerol medium

Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5- b ]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV 365...

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Bibliographic Details
Published in:New journal of chemistry 2018, Vol.42 (12), p.9436-9442
Main Authors: Nongthombam, Geetmani Singh, Kharmawlong, George Kupar, Kumar, John Elisa, Nongkhlaw, Rishanlang
Format: Article
Language:English
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Summary:Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5- b ]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV 365 light source in the absence of a photocatalyst. The reported approach has several advantages such as high yield, clean reaction conditions, chromatography-free synthesis and the use of a cheap water–glycerol solvent system, which is also an environmentally friendly solvent. The applicability of this protocol for the large-scale synthesis of pyrimido[4,5- b ]quinolinone-2,4-diones without wasting any expensive chemicals is an added advantage.
ISSN:1144-0546
1369-9261
DOI:10.1039/C8NJ01459K