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Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD
Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF 5 nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF 5 NPs showed good X-ray attenuation properties and pos...
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| Published in: | New journal of chemistry 2018, Vol.42 (14), p.11565-11572 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423 |
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| cites | cdi_FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423 |
| container_end_page | 11572 |
| container_issue | 14 |
| container_start_page | 11565 |
| container_title | New journal of chemistry |
| container_volume | 42 |
| creator | Wang, Tao Jia, Guorong Cheng, Chao Wang, Qiuhu Li, Xiao Liu, Yanyan He, Chaofan Chen, Luguang Sun, Gaofeng Zuo, Changjing |
| description | Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF
5
nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF
5
NPs showed good X-ray attenuation properties and positive MR contrast effects
in vitro
. Considering that the overexpression of integrin α
v
β
3
in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin α
v
β
3
specifically, was connected to the surface of PEG-BaGdF
5
NPs. The resulting RGD-PEG-BaGdF
5
NPs had good biocompatibility and a long half-life
in vivo
. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF
5
NPs or PEG-BaGdF
5
NPs, respectively. Therefore, the RGD-PEG-BaGdF
5
NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors
via
an active RGD-mediated vasculature targeting pathway. |
| doi_str_mv | 10.1039/C8NJ01527A |
| format | article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C8NJ01527A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1039_C8NJ01527A</sourcerecordid><originalsourceid>FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423</originalsourceid><addsrcrecordid>eNpFUE1LxDAUDKLgunrxF-Qs1M1L03RzrHW3KusHSxFvJU3S2qUfS9Ku7L-3VcHDMMMw8-ANQtdAboH4YhEvX54IBDSMTtAMfC48QTmcjhoY80jA-Dm6cG5HCEDIYYb2keqrg8G9tKXpjcZ6kLXXdFrWOE4Xz1tcNbKs2hJ3BX7_oLgfms46PLjJe1slx1pOtTuZ6DUOcCvbbi9tX6naOKy6djeUP4Gvqv_E2-T-Ep0Vsnbm6o_nKF2v0vjB27wmj3G08VTIIw-YFooboak2dCn8XCgNTBFguaCG09DIImDMBIoQTgMoJPNzkJyFjJoR_hzd_J5VtnPOmiLb2_ETe8yAZNNU2f9U_jdKiVqy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Wang, Tao ; Jia, Guorong ; Cheng, Chao ; Wang, Qiuhu ; Li, Xiao ; Liu, Yanyan ; He, Chaofan ; Chen, Luguang ; Sun, Gaofeng ; Zuo, Changjing</creator><creatorcontrib>Wang, Tao ; Jia, Guorong ; Cheng, Chao ; Wang, Qiuhu ; Li, Xiao ; Liu, Yanyan ; He, Chaofan ; Chen, Luguang ; Sun, Gaofeng ; Zuo, Changjing</creatorcontrib><description>Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF
5
nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF
5
NPs showed good X-ray attenuation properties and positive MR contrast effects
in vitro
. Considering that the overexpression of integrin α
v
β
3
in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin α
v
β
3
specifically, was connected to the surface of PEG-BaGdF
5
NPs. The resulting RGD-PEG-BaGdF
5
NPs had good biocompatibility and a long half-life
in vivo
. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF
5
NPs or PEG-BaGdF
5
NPs, respectively. Therefore, the RGD-PEG-BaGdF
5
NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors
via
an active RGD-mediated vasculature targeting pathway.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/C8NJ01527A</identifier><language>eng</language><ispartof>New journal of chemistry, 2018, Vol.42 (14), p.11565-11572</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423</citedby><cites>FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423</cites><orcidid>0000-0002-2051-766X ; 0000-0001-6228-7578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Jia, Guorong</creatorcontrib><creatorcontrib>Cheng, Chao</creatorcontrib><creatorcontrib>Wang, Qiuhu</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Liu, Yanyan</creatorcontrib><creatorcontrib>He, Chaofan</creatorcontrib><creatorcontrib>Chen, Luguang</creatorcontrib><creatorcontrib>Sun, Gaofeng</creatorcontrib><creatorcontrib>Zuo, Changjing</creatorcontrib><title>Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD</title><title>New journal of chemistry</title><description>Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF
5
nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF
5
NPs showed good X-ray attenuation properties and positive MR contrast effects
in vitro
. Considering that the overexpression of integrin α
v
β
3
in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin α
v
β
3
specifically, was connected to the surface of PEG-BaGdF
5
NPs. The resulting RGD-PEG-BaGdF
5
NPs had good biocompatibility and a long half-life
in vivo
. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF
5
NPs or PEG-BaGdF
5
NPs, respectively. Therefore, the RGD-PEG-BaGdF
5
NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors
via
an active RGD-mediated vasculature targeting pathway.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpFUE1LxDAUDKLgunrxF-Qs1M1L03RzrHW3KusHSxFvJU3S2qUfS9Ku7L-3VcHDMMMw8-ANQtdAboH4YhEvX54IBDSMTtAMfC48QTmcjhoY80jA-Dm6cG5HCEDIYYb2keqrg8G9tKXpjcZ6kLXXdFrWOE4Xz1tcNbKs2hJ3BX7_oLgfms46PLjJe1slx1pOtTuZ6DUOcCvbbi9tX6naOKy6djeUP4Gvqv_E2-T-Ep0Vsnbm6o_nKF2v0vjB27wmj3G08VTIIw-YFooboak2dCn8XCgNTBFguaCG09DIImDMBIoQTgMoJPNzkJyFjJoR_hzd_J5VtnPOmiLb2_ETe8yAZNNU2f9U_jdKiVqy</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Wang, Tao</creator><creator>Jia, Guorong</creator><creator>Cheng, Chao</creator><creator>Wang, Qiuhu</creator><creator>Li, Xiao</creator><creator>Liu, Yanyan</creator><creator>He, Chaofan</creator><creator>Chen, Luguang</creator><creator>Sun, Gaofeng</creator><creator>Zuo, Changjing</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2051-766X</orcidid><orcidid>https://orcid.org/0000-0001-6228-7578</orcidid></search><sort><creationdate>2018</creationdate><title>Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD</title><author>Wang, Tao ; Jia, Guorong ; Cheng, Chao ; Wang, Qiuhu ; Li, Xiao ; Liu, Yanyan ; He, Chaofan ; Chen, Luguang ; Sun, Gaofeng ; Zuo, Changjing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c76A-14d9c6e9d2de2893b9cd14c014b92e627eaf544e5c006251fa43b1a64742e7423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Jia, Guorong</creatorcontrib><creatorcontrib>Cheng, Chao</creatorcontrib><creatorcontrib>Wang, Qiuhu</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Liu, Yanyan</creatorcontrib><creatorcontrib>He, Chaofan</creatorcontrib><creatorcontrib>Chen, Luguang</creatorcontrib><creatorcontrib>Sun, Gaofeng</creatorcontrib><creatorcontrib>Zuo, Changjing</creatorcontrib><collection>CrossRef</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tao</au><au>Jia, Guorong</au><au>Cheng, Chao</au><au>Wang, Qiuhu</au><au>Li, Xiao</au><au>Liu, Yanyan</au><au>He, Chaofan</au><au>Chen, Luguang</au><au>Sun, Gaofeng</au><au>Zuo, Changjing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD</atitle><jtitle>New journal of chemistry</jtitle><date>2018</date><risdate>2018</risdate><volume>42</volume><issue>14</issue><spage>11565</spage><epage>11572</epage><pages>11565-11572</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF
5
nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF
5
NPs showed good X-ray attenuation properties and positive MR contrast effects
in vitro
. Considering that the overexpression of integrin α
v
β
3
in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin α
v
β
3
specifically, was connected to the surface of PEG-BaGdF
5
NPs. The resulting RGD-PEG-BaGdF
5
NPs had good biocompatibility and a long half-life
in vivo
. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF
5
NPs or PEG-BaGdF
5
NPs, respectively. Therefore, the RGD-PEG-BaGdF
5
NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors
via
an active RGD-mediated vasculature targeting pathway.</abstract><doi>10.1039/C8NJ01527A</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2051-766X</orcidid><orcidid>https://orcid.org/0000-0001-6228-7578</orcidid></addata></record> |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| title | Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF 5 nanoparticles conjugated with RGD |
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