New model of metalloantibiotic: synthesis, structure and biological activity of a zinc() mononuclear complex carrying two enrofloxacin and sulfadiazine antibiotics

A new model of the Zn-based complex, [Zn(LH)(Erx)(ErxH)]ClO 4 (sulfadiazine: LH and enrofloxacin ErxH), has been synthesised with two different, but complementary antibiotics (sulfonamide and quinolon) following an easy procedure. To evaluate the synergetic effect of this multicomponent molecule, th...

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Bibliographic Details
Published in:New journal of chemistry 2018, Vol.42 (18), p.15346-15352
Main Authors: Boughougal, Amina, Cherchali, Fatma Zohra, Messai, Amel, Attik, Nina, Decoret, Dominique, Hologne, Maggy, Sanglar, Corinne, Pilet, Guillaume, Tommasino, Jean Bernard, Luneau, Dominique
Format: Article
Language:English
Subjects:
Ammonia
Analytical chemistry
Antibiotics
Biological activity
Chemical Sciences
Crystal structure
Single crystals
Sulfonamides
X-ray diffraction
Zinc
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Summary:A new model of the Zn-based complex, [Zn(LH)(Erx)(ErxH)]ClO 4 (sulfadiazine: LH and enrofloxacin ErxH), has been synthesised with two different, but complementary antibiotics (sulfonamide and quinolon) following an easy procedure. To evaluate the synergetic effect of this multicomponent molecule, the mononuclear complexes [Zn(L) 2 (H 2 O)(NH 3 )] and [Zn(Erx) 3 ] − which each include only one of the two antibiotics (sulfadiazine: LH or enrofloxacin ErxH) were synthesized. All three compounds were characterized, including crystal structure determination by single-crystal X-ray diffraction. For all of the complexes, enrofloxacin is coordinated to Zn( ii ) by pyridinone and one oxygen atom of the carboxylate group in a monodente mode. The antibacterial activity, determined by the minimum inhibitory concentration on specific bacteria, has been studied on free ligands, on the corresponding mononuclear complexes and on our model. Synthesis of a new model of the Zn-based complex with two complementary antibiotics (sulfonamide and quinolone).
ISSN:1144-0546
1369-9261
DOI:10.1039/c8nj01774c