NaOH-promoted reaction of 1,1-dihaloalkenes and 1 H -azoles: synthesis of dihetaryl substituted alkenes

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1 H -azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionali...

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Bibliographic Details
Published in:New journal of chemistry 2018-10, Vol.42 (21), p.17732-17739
Main Authors: Zhang, Chen, Shi, Yu-Long, Zhang, Li-Yu, Yuan, Dong-Peng, Ban, Meng-Tao, Zheng, Jia-Yao, Liu, Deng-Hui, Guo, Shun-Na, Cui, Dong-Mei
Format: Article
Language:English
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Summary:An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1 H -azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.
ISSN:1144-0546
1369-9261
DOI:10.1039/C8NJ02756K