The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

Covering: 2006 to 2018 The application of the 6π-azaelectrocyclization of azatrienes as a key strategy for the synthesis of natural products, their analogs and related bioactive or biomedically-relevant compounds (from 2006 to date) is comprehensively reviewed. Details about reaction optimization st...

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Bibliographic Details
Published in:Natural product reports 2019-02, Vol.36 (2), p.354-41
Main Authors: Vargas, Didier F, Larghi, Enrique L, Kaufman, Teodoro S
Format: Article
Language:English
Subjects:
Biological activity
Natural products
Optimization
Reaction mechanisms
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Summary:Covering: 2006 to 2018 The application of the 6π-azaelectrocyclization of azatrienes as a key strategy for the synthesis of natural products, their analogs and related bioactive or biomedically-relevant compounds (from 2006 to date) is comprehensively reviewed. Details about reaction optimization studies, relevant reaction mechanisms and conditions are also discussed. The stepwise construction of azatrienes and their 6π-azaelectrocyclization en route to the total synthesis of natural products, bioactive heterocycles and other complex molecules, is discussed.
ISSN:0265-0568
1460-4752
DOI:10.1039/c8np00014j