Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance. Access to hydantoin cores via a [3 + 2] annu...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018-11, Vol.16 (43), p.811-814
Main Authors: Sun, Shaofa, Chen, Rongxing, Wang, Gangqiang, Wang, Jian
Format: Article
Language:English
Subjects:
Chemical reactions
Crystallography
Functional groups
Isocyanates
Organic chemistry
Sodium
Sodium carbonate
Substrates
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Summary:A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance. Access to hydantoin cores via a [3 + 2] annulation of α-halohydroxamates and isocyanates involving aza-oxyallyl cations.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02321b