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Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction

The purpose of this study was to develop a novel porous titanium material with superior mechanical strength and osteoconduction for bone reconstruction. Porous titanium samples were fabricated by titanium-slurry impregnate to prepare urethane forms with several porosities (high-porosity; 92%, middle...

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Bibliographic Details
Published in:RSC advances 2019-01, Vol.9 (3), p.1625-1631
Main Authors: Kobatake, Reiko, Doi, Kazuya, Kubo, Takayasu, Makihara, Yusuke, Oki, Yoshifumi, Yokoi, Miyuki, Umehara, Hanako, Tsuga, Kazuhiro
Format: Article
Language:English
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Summary:The purpose of this study was to develop a novel porous titanium material with superior mechanical strength and osteoconduction for bone reconstruction. Porous titanium samples were fabricated by titanium-slurry impregnate to prepare urethane forms with several porosities (high-porosity; 92%, middle-porosity; 85% and low-porosity; 65%). Porous HA (mean porosity; 75.3%) was used as a control. To evaluate the characteristics of these materials, we performed porosity measurements, scanning electron microscopy (SEM), three-point bending testing, and cell proliferation assays. To evaluate the osteoconduction ability, porous titanium was placed into the femurs of rabbits and histological and histomorphometric evaluations were performed after 3 weeks. In SEM images, porous three-dimensional structures were observed in all samples. The bending strength significantly increased as porosity increased (Ti-65 > Ti-85 > porous HA > Ti-92, P < 0.05; respectively). Ti-65, Ti-85, and porous HA showed good cell proliferation. Newly formed bone was observed in the central portion of Ti-65, Ti-85, and porous HA. Ti-92 was mainly detected in the bone marrow tissue. The bone formation areas of Ti-65, Ti-85, and porous HA were significantly higher than that of Ti-92 ( P < 0.05). It was suggested that novel developed porous titanium composed of Ti-65 and Ti-85 showed superior mechanical strength and osteoconduction. The purpose of this study was to evaluate the characteristic structures and osteoconduction ability of porous titanium structures using a resin-impregnated titanium substitution fabrication technique.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra08744j