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Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan
In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel-Craft reaction between acrylic acid and the PSf membrane surface....
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| Published in: | RSC advances 2019-02, Vol.9 (11), p.6254-6266 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c454t-5e9daa9e74940db538e884f8fe64704b2180dbaf530347296b656b178224cef53 |
| container_end_page | 6266 |
| container_issue | 11 |
| container_start_page | 6254 |
| container_title | RSC advances |
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| creator | Tu, Ming-Ming Xu, Jing-Jie Qiu, Yun-Ren |
| description | In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel-Craft reaction between acrylic acid and the PSf membrane surface. Then, the modified SHPCS-AA-PSf membrane was prepared by grafting SHPCS onto the AA-PSf membrane surface
via
the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the -COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm
−2
) compared with the pristine PSf membrane (341 μg cm
−2
). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.
In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. |
| doi_str_mv | 10.1039/c8ra10573a |
| format | article |
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via
the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the -COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm
−2
) compared with the pristine PSf membrane (341 μg cm
−2
). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.
In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c8ra10573a</identifier><identifier>PMID: 35517280</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acids ; Acrylic acid ; Acrylics ; Acylation ; Carboxyl group ; Chemistry ; Chitosan ; Clotting ; Dehydration ; Friedel-Crafts reaction ; Grafting ; Polysulfone resins ; Protein adsorption ; Proteins ; Prothrombin ; Thrombin ; Thromboplastin</subject><ispartof>RSC advances, 2019-02, Vol.9 (11), p.6254-6266</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-5e9daa9e74940db538e884f8fe64704b2180dbaf530347296b656b178224cef53</citedby><cites>FETCH-LOGICAL-c454t-5e9daa9e74940db538e884f8fe64704b2180dbaf530347296b656b178224cef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35517280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Ming-Ming</creatorcontrib><creatorcontrib>Xu, Jing-Jie</creatorcontrib><creatorcontrib>Qiu, Yun-Ren</creatorcontrib><title>Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel-Craft reaction between acrylic acid and the PSf membrane surface. Then, the modified SHPCS-AA-PSf membrane was prepared by grafting SHPCS onto the AA-PSf membrane surface
via
the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the -COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm
−2
) compared with the pristine PSf membrane (341 μg cm
−2
). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.
In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility.</description><subject>Acids</subject><subject>Acrylic acid</subject><subject>Acrylics</subject><subject>Acylation</subject><subject>Carboxyl group</subject><subject>Chemistry</subject><subject>Chitosan</subject><subject>Clotting</subject><subject>Dehydration</subject><subject>Friedel-Crafts reaction</subject><subject>Grafting</subject><subject>Polysulfone resins</subject><subject>Protein adsorption</subject><subject>Proteins</subject><subject>Prothrombin</subject><subject>Thrombin</subject><subject>Thromboplastin</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kk2PFCEQhonRuJt1L941GC8bk1GggaYvm0wm60eyiYkfZ1JNwwwbummhe2L_AX-3uLOOqwe5VFHvQ-WFAqGnlLympGreGJWAElFX8ACdMsLlihHZPLyXn6DznG9IWVJQJuljdFIJQWumyCn68XlODozFO9tHE_sRJt8Gi_vYeedN2cUBR4fHGJY8BxeHotm-TVCSvQds4h6CHaaw4G0CN_lhi8GkJXhTou8wDB0-nITJdni3dCl-X8YUxyVgs_NTzDA8QY8chGzP7-IZ-vr26svm_er647sPm_X1ynDBp5WwTQfQ2Jo3nHStqJRVijvlrOQ14S2jqpTBiYpUvGaNbKWQLa0VY9zYUj5Dl4e-49z2tjPFeIKgx-R7SIuO4PXfyuB3ehv3uiGS1YyVBhd3DVL8Nts86d5nY0Mo7xHnrJmUlNRNJauCvvwHvYlzGsr1dPHJFZfklnp1oEyKOSfrjmYo0b8mrDfq0_p2wusCP79v_4j-nmcBnh2AlM1R_fNFiv7if7oeO1f9BMt3ufg</recordid><startdate>20190221</startdate><enddate>20190221</enddate><creator>Tu, Ming-Ming</creator><creator>Xu, Jing-Jie</creator><creator>Qiu, Yun-Ren</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190221</creationdate><title>Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan</title><author>Tu, Ming-Ming ; Xu, Jing-Jie ; Qiu, Yun-Ren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-5e9daa9e74940db538e884f8fe64704b2180dbaf530347296b656b178224cef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acids</topic><topic>Acrylic acid</topic><topic>Acrylics</topic><topic>Acylation</topic><topic>Carboxyl group</topic><topic>Chemistry</topic><topic>Chitosan</topic><topic>Clotting</topic><topic>Dehydration</topic><topic>Friedel-Crafts reaction</topic><topic>Grafting</topic><topic>Polysulfone resins</topic><topic>Protein adsorption</topic><topic>Proteins</topic><topic>Prothrombin</topic><topic>Thrombin</topic><topic>Thromboplastin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tu, Ming-Ming</creatorcontrib><creatorcontrib>Xu, Jing-Jie</creatorcontrib><creatorcontrib>Qiu, Yun-Ren</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tu, Ming-Ming</au><au>Xu, Jing-Jie</au><au>Qiu, Yun-Ren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2019-02-21</date><risdate>2019</risdate><volume>9</volume><issue>11</issue><spage>6254</spage><epage>6266</epage><pages>6254-6266</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel-Craft reaction between acrylic acid and the PSf membrane surface. Then, the modified SHPCS-AA-PSf membrane was prepared by grafting SHPCS onto the AA-PSf membrane surface
via
the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the -COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm
−2
) compared with the pristine PSf membrane (341 μg cm
−2
). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.
In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35517280</pmid><doi>10.1039/c8ra10573a</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2019-02, Vol.9 (11), p.6254-6266 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C8RA10573A |
| source | PubMed Central |
| subjects | Acids Acrylic acid Acrylics Acylation Carboxyl group Chemistry Chitosan Clotting Dehydration Friedel-Crafts reaction Grafting Polysulfone resins Protein adsorption Proteins Prothrombin Thrombin Thromboplastin |
| title | Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan |
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