A cellular automaton for modeling non-trivial biomembrane ruptures

A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models and bond-based fracture methods. The model is demonstrated by comparing simula...

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Published in:Soft matter 2019-05, Vol.15 (2), p.4178-4186
Main Authors: Gupta, Abhay, Gözen, Irep, Taylor, Michael
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Language:English
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description A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models and bond-based fracture methods. The model is demonstrated by comparing simulations with experimental results of a double bilayer lipid membrane expanding on a solid substrate. Results indicate that the CA can capture non-trivial rupture morphologies such as floral patterns and the saltatory dynamics of fractal avalanches observed in experiments. Moreover, the CA provides insight into the poorly understood role of inter-layer adhesion, supporting the hypothesis that the density of adhesion sites governs rupture morphology. A cellular automaton capturing experimentally observed floral and fractal avalanche rupture morphologies in self-spreading double lipid bilayers.
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title A cellular automaton for modeling non-trivial biomembrane ruptures
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