Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter 9 µm, pore size 25 nm) with dioleoylphosphati...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018, Vol.6 (35), p.5633-5639
Main Authors: Pavel, Ileana-Alexandra, Girardon, Maxime, El Hajj, Sarah, Parant, Stéphane, Amadei, Federico, Kaufmann, Stefan, Tanaka, Motomu, Fierro, Vanessa, Celzard, Alain, Canilho, Nadia, Pasc, Andreea
Format: Article
Language:English
Subjects:
Chemical Sciences
Coatings
Controlled release
Drug delivery
Enzymes
Galactosidase
Intestine
Intolerance
Lactose
Lecithin
Membranes
Microparticles
Nanoparticles
Pancreatin
Phosphatidylcholine
Phospholipids
Pore size
Porosity
Porous materials
Protective coatings
Silica
Silicon dioxide
Tempering
β-Galactosidase
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creator Pavel, Ileana-Alexandra
Girardon, Maxime
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Celzard, Alain
Canilho, Nadia
Pasc, Andreea
description β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter 9 µm, pore size 25 nm) with dioleoylphosphatidylcholine membranes significantly improved the loading capability and protected the enzymes from the loss of function under simulated gastric conditions. Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional β-galactosidase. The coating of mesoporous silica nanoparticles with a single phospholipid bilayer opens up a large potential towards the controlled release of orally administrated drugs or enzymes to the intestines. Coating of mesoporous silica carriers with dioleoylphosphatidylcholine allowed triggering of the selective delivery of functional enzymes by lipolysis under simulated intestinal conditions.
doi_str_mv 10.1039/c8tb01114a
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Chemical Sciences
Coatings
Controlled release
Drug delivery
Enzymes
Galactosidase
Intestine
Intolerance
Lactose
Lecithin
Membranes
Microparticles
Nanoparticles
Pancreatin
Phosphatidylcholine
Phospholipids
Pore size
Porosity
Porous materials
Protective coatings
Silica
Silicon dioxide
Tempering
β-Galactosidase
title Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines
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