Platinum nanoworms for imaging-guided combined cancer therapy in the second near-infrared window

Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to the high light penetration depth and minimal optical scattering in the NIR II region (1000-1350 nm). Meanwhile, integrating multiple diagnostic and therapeutic functions into one simple na...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-08, Vol.6 (31), p.569-579
Main Authors: Ma, Qingxi, Cheng, Liang, Gong, Fei, Dong, Ziliang, Liang, Chao, Wang, Mengyun, Feng, Liangzhu, Li, Yonggang, Liu, Zhuang, Li, Can, He, Lin
Format: Article
Language:English
Subjects:
Absorption
Attenuation
Biocompatibility
Blood circulation
Cancer
Cancer therapies
Computed tomography
Contrast agents
Diagnostic systems
Hypoxia
I.R. radiation
Infrared imaging
Infrared windows
Light penetration
Medical imaging
Nanoparticles
Penetration depth
Platinum
Precision medicine
Radiation therapy
Toxicity
Tumors
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Summary:Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to the high light penetration depth and minimal optical scattering in the NIR II region (1000-1350 nm). Meanwhile, integrating multiple diagnostic and therapeutic functions into one simple nanoparticle system is of vital significance for cancer theranostics. Herein, we prepare worm-like platinum (Pt) nanoparticles (Pt nanoworms) in a facile way. The Pt nanoworms with surface modification show long blood circulation, high tumor accumulation, and negligible toxicity. With high optical absorption in the NIR II region and strong X-ray attenuation abilities, the Pt nanoworms serve as a good photoacoustic agent and CT contrast agent. Meanwhile, the tumor growth is completely inhibited by using mild photothermal therapy and radiotherapy due to the photothermally improved hypoxia and Pt increased X-ray absorption. Therefore, our work presents a biocompatible platinum nanoparticle system that is promising in image-guided tumor therapy. Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to the high light penetration depth and minimal optical scattering in the NIR II region (1000-1350 nm).
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb01545g