Facile and versatile solid state surface modification of silk fibroin membranes using click chemistry

Reported is a fast and versatile protocol to surface modify pre-cast silk membranes targeting tyrosine residues. Enriched alkyne silk membranes were prepared using this method and azides possessing a range of functional groups were tethered to the membrane surface using click chemistry to give a ran...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-12, Vol.6 (48), p.837-842
Main Authors: Raynal, Laetitia, Allardyce, Benjamin J, Wang, Xungai, Dilley, Rodney J, Rajkhowa, Rangam, Henderson, Luke C
Format: Article
Language:English
Subjects:
Alkynes
Chemical synthesis
Contact angle
Functional groups
Membranes
Organic chemistry
Silk
Silk fibroin
Tyrosine
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Summary:Reported is a fast and versatile protocol to surface modify pre-cast silk membranes targeting tyrosine residues. Enriched alkyne silk membranes were prepared using this method and azides possessing a range of functional groups were tethered to the membrane surface using click chemistry to give a range of water contact angles from 85 ± 3° to 34 ± 6°. Reported is a fast and versatile protocol to surface modify pre-cast silk membranes targeting tyrosine residues.
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb02508h