A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an impor...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (7), p.1424-1427
Main Authors: Lim, Hye Rim, Kim, Seo Yun, Jeon, Eun Hee, Kim, Yun Lan, Shin, Yu Mi, Koo, Tae-Sung, Park, Sung Jean, Hong, Ki Bum, Choi, Sungwook
Format: Article
Language:English
Subjects:
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Blood plasma
Diagnostic software
Diagnostic systems
Fluorescent Dyes - chemistry
Fluorescent indicators
Humans
Limit of Detection
Pathogenesis
Prealbumin - metabolism
Spectrometry, Fluorescence
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Summary:The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix. A robust and simple fluorescent assay for the quantification of TTR in human plasma was developed by utilizing an indole-based fluorophore.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc04172a