Chemical biology suggests pleiotropic effects for a novel hexanuclear copper() complex inducing apoptosis in hepatocellular carcinoma cells

A novel hexanuclear copper( ii )-based complex, [Cu 6 (tpbb) 2 (NO 3 ) 12 ] ( 1 ), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (79), p.11944-11947
Main Authors: Zhang, Junshuai, Hu, Jiyong, Peng, Kun, Song, Wei, Zhi, Shuangcheng, Yang, Endian, Zhao, Jin'an, Hou, Hongwei
Format: Article
Language:English
Subjects:
Apoptosis
Astrochemistry
Bioassays
Biological effects
Cell cycle
Coordination compounds
Copper
Copper compounds
Crystallography
Damage detection
Emission spectra
Molecular docking
Organic chemistry
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel hexanuclear copper( ii )-based complex, [Cu 6 (tpbb) 2 (NO 3 ) 12 ] ( 1 ), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way. A new hexanuclear copper( ii ) complex proved potential chemotherapeutic applicability in inducing apoptosis in cancer calls by acting on multiple targets and signaling pathways.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05995d