Oxyanion transport across lipid bilayers: direct measurements in large and giant unilamellar vesicles

A simple di(thioamido)carbazole 1 serves as a potent multispecific transporter for various biologically relevant oxyanions, such as drugs, metabolites and model organic phosphate. The transport kinetics of a wide range of oxyanions can be easily quantified by a modified lucigenin assay in both large...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (36), p.491-4913
Main Authors: B k, Krzysztof M, van Kolck, Bartjan, Maslowska-Jarzyna, Krystyna, Papadopoulou, Panagiota, Kros, Alexander, Chmielewski, Micha J
Format: Article
Language:English
Subjects:
Biological Transport
Carbazoles
Carbazoles - chemistry
Carbazoles - metabolism
Kinetics
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Lipids
Metabolites
Molecular Structure
Oxygen - chemistry
Oxygen - metabolism
Thioamides - chemistry
Thioamides - metabolism
Transport
Unilamellar Liposomes - chemistry
Unilamellar Liposomes - metabolism
Vesicles
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Summary:A simple di(thioamido)carbazole 1 serves as a potent multispecific transporter for various biologically relevant oxyanions, such as drugs, metabolites and model organic phosphate. The transport kinetics of a wide range of oxyanions can be easily quantified by a modified lucigenin assay in both large and giant unilamellar vesicles. A simple, carbazole-based dithioamide receptor transports a variety of biologically relevant anions through lipid bilayers, as shown by direct fluorescent assays in LUVs and GUVs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09888g